Does the biomarker search paradigm need re-booting?

Does the biomarker search paradigm need re-booting?

The clinical problem of bladder cancer is its high recurrence and progression, and that the most sensitive and specific means of monitoring is cystoscopy, which is invasive and has poor patient compliance. Biomarkers for recurrence and progression could make a great contribution, but in spite of decades of research, no biomarkers are commercially available with the requisite sensitivity and spe...

Bradfordizing evaluated: Does this bibliometric re-ranking technique improve search?

The purpose of this paper is to describe the evaluation of the effectiveness of the bibliometric technique Bradfordizing in an information retrieval (IR) scenario. Bradfordizing is used to rerank topical document sets from conventional abstracting & indexing (A&I) databases into core and more peripheral document zones. Bradfordized lists of journal articles and monographs will be tested in a co...

The need for treatment interruption studies and biomarker identification in the search for an HIV cure.

The evaluation of new therapies to achieve an antiretroviral therapy (ART)-free remission of HIV infection will require demonstration of efficacy through ART interruption studies. However, there are concerns about stopping ART, including patient safety, selection of HIV drug resistance and increased risk for HIV transmission. In this article, we highlight the importance of identifying biomarker...

The need for a new paradigm.

Since the start of the rational-expectations revolution in the mid 1970s, macroeco­ nomic analysis has been dominated by the assumption of the rational representative agent. This assumption has now become the main building block of macroeconomic modeling, so much so that macroeconomic models without a microfoundation based on the rationality assumption are simply no longer taken seriously. The ...

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